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Home / Blog / The influence of medicine packaging materials on the quality of medicines
The influence of medicine packaging materials on the quality of medicines January 29,2021.

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    Pharmaceutical packaging materials will have an impact on the effectiveness of the use of drugs. Therefore, drug management personnel must strengthen the review and management of pharmaceutical packaging materials to ensure the safety of pharmaceutical packaging materials to avoid harm to the human body. Drug packaging management personnel need to take responsibility for all aspects of drug production and packaging to ensure the safety of people using drugs.


1. Current status of use of pharmaceutical packaging materials

    Pharmaceutical packaging materials refer to outer packaging materials and pharmaceutical filling materials that are used to protect and store and directly contact pharmaceuticals. They are called pharmaceutical packaging materials. In general, they are materials used to make pharmaceutical storage containers. The main function of drug packaging is to protect drugs from environmental influences, to preserve their drug effects, and to ensure that they can be preserved intact during transportation and sales. Generally speaking, packaging materials are divided into three categories:

    (1) The packaging closest to the medicine;

    (2) Packaging materials that can be in close contact with medicinal materials, but can be recycled and reused, but need to go through strict cleaning before they can be used again;

    (3) It can be in direct contact with drugs, but it will have a certain impact on the quality of the drugs and affect the effectiveness of the drugs. The third type of packaging materials for medicinal materials will not only reduce the therapeutic effect of drugs, but also produce some harmful substances to the human body, causing human body function diseases. Therefore, more attention must be paid to the management of pharmaceutical packaging materials, and pharmaceutical companies are strictly required to strengthen supervision. At present, the drug packaging management plan is gradually mature, and the control of drug quality has gradually become the focus of social attention. The strict law enforcement by relevant departments during supervision has ensured the quality of drug packaging, and the use of packaging materials has gradually shown a diversified development. , Plastic, metal, etc. have become common materials in pharmaceutical packaging. Among these materials, the glass material has a strong ability to protect medicines, and can store medicines for a long time, so that the efficacy of the medicines can not be damaged for a long time, but it is easy to be damaged during transportation, and it is not convenient to carry and use. Shortcomings. Plastic materials are more convenient to transport during use, can be used to synthesize more new materials, and the use cost is lower, but its protective effect for medicines is poor. In the process of use, metal materials can better protect the medicines and prevent the medicines from deteriorating from moisture. The aesthetics and convenience of their packaging are also popular types, but their use costs are relatively high. The advantages and disadvantages of different materials are relatively clear. With the continuous development of science and technology, alternative materials to the original materials are gradually being developed, which significantly improves the protection of drugs. However, for the selection of materials, we should not blindly pursue new technologies. Only by combining the properties of related drugs to determine, can the stability of the drug effect be better protected and its therapeutic effect on human diseases [1].


2. The impact of drug packaging materials on drug quality

    Drugs circulating in the market have different packaging methods, and there are certain hidden safety hazards in the packaging of drugs. The main reason for the hidden dangers is that there is no combination of scientific production methods and strict material selection in the manufacturing process, or the manufacturer chooses cheaper materials in pursuit of high profits, and does not consider that unqualified packaging materials may lead to the quality of medicines. affected.

    2.1 Material characteristics of glass containers and their impact on drug quality

    Glass materials are common materials in daily life. Many medicines are contained in glass containers. The color and style of glass containers are also changeable, and the overall appearance is better. In addition, the sealing performance of the glass container is strong, which can store the medicines more stably, prevent the medicines from being contaminated, and protect the activity of some easily decomposable substances. Isolating the medicine from the air can prevent the occurrence of oxidation reaction, so as to prevent the deterioration of the medicine and produce substances that harm human health. Therefore, the packaging of glass materials is loved by the majority of manufacturers, and it also earns greater profits for the merchants. The disadvantage of glass is that it is not strong enough, and a slight bump will cause it to break. When transporting and selling medicines, it is necessary to add more protective measures around them and place them in a safer environment to ensure their safety. In addition, glass materials cannot withstand pressure. If there is a certain amount of squeezing, the glass will also be damaged. If the glass material is broken, the resulting residue will hurt the user. Therefore, when choosing the glass material, it is necessary to make a careful choice based on the use of medicines. A large number of experiments have found that some medicines easily react with glass materials and produce unknown substances, which will affect human health. For example, when insulin is placed in a glass instrument, insulin can chemically react with substances such as silicon dioxide and boron oxide in the glass, causing its effect to fail. In addition, there are also clear regulations in the Chinese Pharmacopoeia, stating that certain substances cannot be stored using glass materials [2].

    2.2 The characteristics of rubber materials and their impact on drug quality

    With the gradual maturity of rubber use technology, rubber materials have become one of the important materials for pharmaceutical packaging. When glass bottles are used for drug storage, rubber stoppers are generally used to seal the bottle mouth. General rubber materials can be roughly summarized into two categories: natural rubber and butyl rubber. Different rubbers also have certain differences in their functions. Relevant experiments have shown that natural rubber can play a small protective role for corrosive drugs, and will quickly react with the drugs, resulting in damage to the bottle seal. But butyl rubber does not react quickly and has relatively stable properties. However, the configuration method is more complicated and the probability of success is low. If there is a problem with the production method, there will be more impurities in the rubber product, and these impurities will react with the ingredients in the medicine, which will reduce the efficacy of the medicine.

    2.3 The characteristics of plastic materials and their impact on the quality of medicines

    Plastic materials are the most common packaging materials in the market. For manufacturers, they have the characteristics of relatively low cost and wide range of use, which can save a lot of money and seek more economic benefits for them. Therefore, many manufacturers use plastic materials for pharmaceutical packaging. In addition, plastics can be loaded more conveniently during transportation, and there is no need to worry about being damaged during transportation. Its airtightness can also ensure that the medicine is not affected by air, so that the effect of the medicine can be maximized. At the same time, its lightweight packaging can also meet people's needs for travel. The materials used in the production of plastic materials are mainly polyethylene, polypropylene, and polyvinyl chloride. The use of these materials may cause harm to some medicines, accelerate the deterioration of medicines, and produce substances harmful to the human body. Therefore, when using plastic materials, it is necessary to conduct sufficient research on pharmaceutical ingredients and plastic ingredients to find the most suitable packaging materials.

    2.4 The characteristics of metal materials and their impact on drug quality

There are many types of metal materials, of which aluminum is the most common one, and is most commonly used in pharmaceutical packaging materials. Aluminum has a long service life, is not susceptible to the influence of air, and rust occurs, so it is often selected as a pharmaceutical packaging material. The better ductility and plasticity of aluminum products bring more possibilities for their appearance and can bring better economic benefits. Other types of metal materials will react with the drugs to a certain extent during the packaging of drugs and produce more impurities, which will have an adverse effect on the people who use the drugs and lead to a decline in human health [3].


3. Measures to strengthen the safety performance of pharmaceutical packaging materials

    Although the society has paid more attention to the supervision of drug quality and the supervision technology has also been improved to a certain extent, the problem of drug quality still exists, and there are no few problems related to packaging. In order to pursue economic benefits, some businesses beautify the packaging of medicines, relying on the gorgeous appearance to increase sales. However, actual research has found that when certain materials are used for packaging, the use parameters are fixed and cannot be changed at will. If there is a deviation, it will lead to a decline in the effectiveness of the drug. Therefore, it is necessary to strictly follow the regulations of the pharmacopoeia during the production of drugs and find the most suitable packaging method to provide a guarantee for the development of the pharmaceutical industry.

    3.1 Pay attention to material safety

    Drug packaging supervision should start with packaging materials, and when selecting materials, materials with higher safety should be selected. The most important thing is to make a selection based on the actual situation of the medicine. At the same time, it is also necessary to consider the environment of the production workshop to avoid the surrounding environment from affecting the medicine. For example, for substances that are prone to oxidation reactions, packaging operations must be carried out in a closed space to reduce pollution caused by air flow. The safety of the material is also reflected in its own non-toxicity and the stability of the structural properties, so it is necessary to ensure that the packaging material does not react with the drug [4].

    3.2 Perform comprehensive performance analysis

    Each medicine is unique and produces different therapeutic effects for different diseases. Therefore, when packaging it, strict analysis should be carried out according to its performance. Packaging personnel need to accurately understand the nature of packaging materials and the effects and characteristics of drugs, and through comprehensive analysis, can they determine a scientific and reasonable packaging method. In addition, when packaging, we should also pay attention to the hygiene of the production line. If the materials used are more polluted and not clean enough, they will also pollute the drugs.


Conclusion

    Drugs generally use different packaging during the production process, and the materials used in some drug packaging will affect the effectiveness of the drug, and even endanger human health in severe cases. After a large number of market investigations, it was discovered that the actual quality and safety of the drugs were not strictly supervised, and the packaging materials of the drugs did not meet the strict national regulations. Therefore, drug management personnel must strengthen the review and management of drug packaging materials to ensure the safety of drug packaging materials to avoid harm to the human body. The entire pharmaceutical packaging market needs to be healthier and more stable, and crack down on illegal activities that make illegal profits through pharmaceutical packaging.

Guangzhou Biaoji Packaging Equipment Co.,Ltd is a professional manufacturer focused on developing and producing mask testing instruments and focused on developing packaging material test instruments . and spouting machine Founded in 2002 the company has received IOS 9001 certification and recognized as high-tech enterprise and software enterprise by national authority. We hold numerous technology patents and software certificates from the national authority, and gained awards for technological progress.GBPI can provide you with a complete package of drug packaging materials testing program.

Reference:   

[1]songjiali. Analysis of the impact of drug packaging materials on drug quality[J].Heilongjiang Science and Technology Information,2016(04):3.  

[2]Wu Lumin,Liu Weifen,Li Luhui.Packaging of clopidogrel hydrogen sulfate tablets Research on the influence of materials on drug quality[J].Science and Technology Vision,2014(20):329+344.  

[3]zhangkai,xushuwen.The impact of plastic packaging materials on drug quality and safety[J].Modern Medicine and Clinic ,2013,28(03):465-467.  

[4]Zhang Jun. Research on Quality Risk Control of R&D of Pharmaceutical Packaging Materials of HM Company[D].Shandong University,2010 This article is reproduced from: Consumer Guide Magazine




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