GBPI Migration Testing Equipment
AUTO ZF3600 Total Migration & Non-Volatile Substance Analyzer
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Overview
The AUTO ZF3600 analyzer for total migration and non-volatile substances adopts an all-in-one framework that integrates water bath vaporization, thermal drying, cooling treatment and gravimetric measurement at constant weight. The whole testing sequence runs autonomously without manual intervention. It is developed for assessing total migration, non-volatile content and evaporation residue for purified water, pharmaceutical packaging components, food contact articles, cigarette tipping paper and chemical reagents. Besides, it supports the measurement of moisture content and loss upon drying of solid specimens, as well as total dissolved solids examination in water quality monitoring.
Testing Mechanism
The test liquid is transferred into the solvent tray of the automated feeding module. The empty dish undergoes programmed heating, cooling and weighing cycles repeatedly until constant mass is achieved. The liquid sample is evaporated to dryness within a water bath maintained below the boiling point of the extraction solvent. The inner chamber is heated up to 105℃ for dehydration and then cooled down. After the evaporating dish cools sufficiently, the balance verifies stable constant weight, and the trial finishes once the constant-mass criterion of the test item is satisfied.
Schematic Illustration of Mechanism

Applicable Standards
- Purified Water: Purified Water specified in Chinese Pharmacopoeia Volume II, EP9.0 WATER, PURIFIED
- Pharmaceutical Packaging: Non-volatile substance test in extractables trials under National Pharmaceutical Packaging Material Specifications
- Food Contact Materials: GB 31604.8-2021, EN 1186-3:2002 method A, Standards and Specifications for Utensils, Containers and Packages of Korea Ministry of Health and Welfare chapter IV 2-8
- Cigarette Tipping Paper: YQ/T 59-2015
- Chemical Reagents: GB/T 9740-2008, ISO 759
- Water Quality: GB 8538-2016, DZT0064.9-2021, GB/T 14415-2007, GB/T 5750.4-2006
- Solid Samples: Extractables and loss on drying in Chinese Pharmacopoeia Volume IV, USP40-NF35<921> WATER DETERMINATION
Technical Parameters
Key Advantages
Dual-chamber Temperature Control with Optimized Automation
The unified workflow covers water bath vaporization, drying, cooling and constant-weight measurement to deliver automated, efficient and precise testing. It adopts an automatic feeding structure managed by pneumatic valves, with residual liquid controlled below 0.1 mL. Operators are freed from waiting and continuous on-site monitoring. The built-in water bath comes with liquid level sensors to realize automatic water level checking, water filling, draining and temperature regulation.
Premium Imported Balances with Isolation Protection Housing
Three high-precision imported balances are embedded inside the unit. A 0.3 mg constant weight outcome can be achieved after two drying cycles. Balances are secured inside a stable protective enclosure fitted with water-circulation interlayer, which maintains steady temperature and humidity throughout weighing operations.
High-throughput Capacity & Broad Compatibility
Thirty-six independent testing stations are equipped with separate data logging channels to support batch testing tasks. Compatible sample solvents include purified water, n-hexane, ethanol, acetic acid, chloroform and other organic solvents.
Cooling & Solvent Recovery Module for Eco-friendly Operation
A built-in circulating chiller sustains low chamber temperature. It can cool the chamber down to ambient temperature within 30 minutes. Matched with solvent collection bottles, the recovery rate of solvent can reach above 90%.
Intelligent Software Platform, Global Compliance Qualification
Real-time display of weight readings, temperature and humidity curves; all data records are saved automatically for later review. Designed following GMP annex for computerized systems, test parameters can be flexibly configured for diverse standard requirements. Audit trail function is available for full data traceability, and role-based access control is supported. Multiple export formats, electronic signature and online report approval functions are integrated.
Smart Laboratory IoT Connection
This analyzer can link to the IoT platform for digital network management. Authorized users can remotely access the instrument interface, manage experimental datasets and carry out remote fault diagnosis via the cloud platform.
Application
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